Functional Groups

Each of the 44 functional groups offers a breadth of potential new drug targets, protein therapeutics and markers for diagnostics. You may obtain non-confidential packages describing selected functional groups that are relevant to your company's discovery pipeline. Such packages include a table of all the genes within the group; for each gene, synonyms, an accession number, a reference to a paper describing the gene, the function and sub-cellular localization are provided.

A database of annotated genes for a selected functional group will be made available under a confidentiality agreement. This database includes, for each gene within a group, a map of "full gene structure" (description of all identified splice variants), SNPs and chromosomal location. Based on your company's specific needs, you may discern those genes that hold a unique potential for your specific pipeline. Your company may enter into an R&D collaboration with Compugen to commercialize products based on selected genes.

Functional group	Description of proteins
ADAPTOR BINDING PROTEINS	Proteins that are associated to other cell components, either by binding, interacting, or associating to them. This interaction is necessary for the protein. s activity and/or structure.
ADHESION MOLECULES	Proteins that serve as adhesion molecules between adjoining cells.
APOLIPOPROTEINS	Proteins that are part of the lipoprotein particle and act as a recognition signal for the cellular binding and internalization of these particles.
APOPTOSIS RELATED GENES	Proteins and enzymes that are involved in the apoptosis pathway, either by inducing or inhibiting it.
CANCER RELATED GENES	Proteins that are involved in cancer: oncogenes, DNA repair proteins, tumor markers and antigens, tumor suppressors, and cellular second messengers that participate in cancer.
CARBOXYLASE	Enzymes that add or remove CO₂ groups.
CELL SURFACE ANTIGENS	Proteins expressed on the surface of cells.
CELL CYCLE	Proteins and enzymes involved in controlling the cell cycle pathway, cellular growth, cell division, and cellular progression.
COAGULATION	Proteins involved in the blood coagulation pathway.
CONVERTING ENZYMES	Enzymes that convert one protein to another by specific cleavage of the precursor protein.
CYCLASE ENZYMES	Enzymes that convert triphosphate to cyclic monophosphate.
DEGRADATION	Proteins and cellular enzymes involved in the degradation process of other proteins.
DEVELOPMENTAL	Proteins affecting development.
DISEASE RELATED	Proteins involved in a certain disease(s), either by contributing to it, or by acting as a marker for it.
DOMAINS INVOLVED IN PROTEIN-PROTEIN INTERACTIONS	Proteins that are involved in protein-protein interactions.
ESTERASES	Enzymes cleaving the ester bond between a chemical residue and a protein.
GROWTH FACTORS	Growth factors, cytokines, interleukins, interferons, and lymphokines.
HORMONES	Hormones, poietin proteins.
HOUSEKEEPING GENES	Homeobox, heat shock proteins and factors, chaperonins.
HYDROLASES	Enzymes that modify the hydroxyl group, such as hydrogenase, dehydrogenase, hydrolase, and hydroxylase.
IMMUNOLOGY RELATED GENES	Proteins that are involved in the immune and complement systems, such as antigens and autoantigens, immunoglobulins, MHC and HLA proteins and their associated proteins.
INHIBITORS	Inhibitors and suppressors of other proteins and enzymes.
KINASES	Kinase.
LIPASES	Lipase, phospholipase, and lysophospholipase.
CELL MATRIX AND CYTOSKELATON	All proteins compromising the cell matrix and cytoskeleton.
MODIFYING ENZYMES	Miscellaneous enzymes such as paraoxonase, GTPase, ATPase, anhydrase.
MUTASES	Mutases and superoxide dismutase.
NEUROLOGY RELATED GENES	CNS related proteins and enzymes.
OXIDASES	Oxidase and peroxidase.
OXYGENASES	Oxygenase, mono- and dio-oxygenase.
PHOSPHATASES	Phosphatases and phosphorylases.
PHOSPHOPROTEINS	Phosphoproteins and phospholipids.
PROTEASES	Proteases, peptidases, and proteinases.
RECEPTORS	Receptors.
REDUCTASES	Reductases.
SECRETED FACTORS	Secreted proteins.
SIGNAL TRANSDUCTION	Proteins that participate in signal transduction, such as G proteins.
SUBCELLULAR	Subcellular proteins, such as ribosomal proteins.
SYNTASES	Syntase, sythases, synthetase.
TRANSCRIPTIONAL RNA/DNA	Nuclear proteins involved in RNA and DNA, such as transcription factors, RNA and DNA binding proteins, zinc fingers, helicase, isomerase, histones, nucleases.
TRANSFERASES	Proteins involved in TRANSFER of functional groups.
TRANSLATIONAL FACTORS	Proteins and enzymes involved in the translational process, such as elongation and initiation factors.
TRANSPORTERS	Proteins that mediate the transport of molecules and macromoleules, such as channels, exchangers, pumps.
TISSUE-SPECIFIC GENES	Proteins expressed specifically in only one tissue, cell type or organ or in a very limited number of tissues or cell types.

Novel gene portfolio

Why are novel splice variants important?